This article critically examines an HIV/AIDS development and research project in Mwanza, Tanzania. A group of women produce a type of probiotic yoghurt that has evidence of lowering the incidence of HIV infection. The yoghurt is consumed by the women, their family members, and local citizens living with HIV/AIDS; surplus is sold within the community. While the project’s multi-partner, multidisciplinary composition allows for varied expertise and insights, it also requires open and collaborative dialogue.